Defects in Cell Growth Regulation by C18:0-Ceramide and Longevity Assurance Gene 1 (LAG1) in Human Head and Neck Squamous Cell Carcinomas (HNSCC)#
نویسندگان
چکیده
From the ¶Departments of Biochemistry and Molecular Biology, †Otolaryngology/Head and Neck Surgery, ‡Medicine and Ralph H. Johnson Veterans Affairs Medical Center, Medical University of South Carolina, Charleston, SC 29425; ∫Louisiana State University Health Sciences Center, Department of Biochemistry and Molecular Biology, New Orleans, LA 70112; and ¥Abant Izzet Baysal University, Izzet Baysal Medical Faculty, Department of Otolaryngology, Bolu, Turkey.
منابع مشابه
Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas.
In this study, endogenous long chain ceramides were measured in 32 human head and neck squamous cell carcinoma (HNSCC) and 10 nonsquamous head and neck carcinoma tumor tissues, as compared with adjacent noncancerous tissues, by liquid chromatography/mass spectroscopy. Interestingly, only one specific ceramide, C(18:0)-ceramide, was selectively down-regulated in the majority of HNSCC tumor tissu...
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In this study, quantitative isobologram studies showed that treatment with gemcitabine and doxorubicin, known inducers of ceramide generation, in combination, supra-additively inhibited the growth of human UM-SCC-22A cells in situ. Then, possible involvement of the human homologue of yeast longevity assurance gene 1 (LASS1)/C(18)-ceramide in chemotherapy-induced cell death in these cells was ex...
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